REDBIO México 2010

Folio: 613
Tipo de presentación: Oral
Tema: Bioseguridad
Este trabajo se presentará en "Presentaciones Libres 20: Biotecnología y Sociedad" el Miercoles dentro del horario 16:40 a 18:40

Application of Food and Feed Safety Assessment Principles to Evaluate Transgenic Approaches to Gene Modulation in Crops

"Wayne Parrott 1*, Bruce Chassy 2, Jim Ligon 3, Linda Meyer 4, Jay Petrick 5, Junguo Zhou 6, Rod Herman 7, Bryan Delaney 8, Marci Levine 9
Dept of Crop and Soil Sciences, University of Georgia, Athens, GA, USA 2 College of ACES, University of Illinois at Urbana, Urban, IL, USA 3 Bayer CropScience, Research Triangle Park, NC, USA, formerly with BASF, Research Triangle Park, NC, USA 4 Syngenta Biotechnology, Inc., Research Triangle Park, NC, USA 5 Monsanto Company, St. Louis, MO, USA 6 Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ, USA; formerly with Bayer CropScience, Research Triangle Park, NC, USA 7 Dow AgroSciences, Indianapolis, IN, USA 8 Pioneer, A DuPont Company, Johnston, IA, USA 9 International Life Sciences Institute, Washington DC, USA"

RESUMEN (ABSTRACT)
"New crop varieties containing traits such as enhanced nutritional profiles, increased yield, and tolerance to drought are being developed. In some cases, these new traits are dependent on small RNAs or regulatory proteins such as transcription factors (TF) that modify the expression of endogenous plant genes. To date, the food and feed safety of genetically modified (GM) crops has been assessed by the application of a set of internationally accepted procedures for evaluating the safety of GM crops. The goal of this paper is to review the main aspects of the current safety assessment paradigm and to recommend scientifically sound principles for conducting a safety assessment for GM crops that are developed by technologies that modify endogenous plant gene expression. Key considerations for such a safety assessment include the following: 1) RNA and TF are generally recognized as safe (GRAS); 2) Genes encoding RNAi and regulatory proteins such as TFs are an important component of the plant genome; 3) Crops engineered using RNAi modifications are not expected to produce heterologous proteins; 4) The modulation of TFs may result in quantitative differences in endogenous plant components, which can be assessed through agronomic performance and compositional analysis on a case-by-case basis."